2 edition of Cellular mechanisms in the regulation of gastric secretory cells found in the catalog.
Cellular mechanisms in the regulation of gastric secretory cells
Rakhmetkaji I. Bersimbaev
Includes bibliographical references and index.
|Statement||Rakhmetkaji I. Bersimbaev, Karl-Friedrich Sewing, Winfried Beil.|
|Contributions||Beil, Winfried., Sewing, Karl-Friedrich.|
|LC Classifications||QP151 .B47 1993|
|The Physical Object|
|Pagination||219 p. :|
|Number of Pages||219|
The mechanisms are similar to that of the mucous cells of the stomach, except that large quantities of fluid are also produced. Carbon dioxide and water enter the cell and combine to form carbonic acid under the influence of the enzyme carbonic anhydrase. The acid-secreting parietal cells of the stomach and distal tubule cells of the kidney N. Cell Physiology Source Book Dissects the molecular mechanisms of pH regulation .
Although the digestive functions of the stomach facilitate release of nutrients from food, the only secretory function of the stomach critical for life is synthesis and release of Intrinsic Factor. Because of its complex regulation, secretion of stomach acid is covered on its own page: Stomach Acid Secretion. One secretory product of considerable importance in man is intrinsic factor, a glycoprotein secreted by parietal cells that is necessary for intestinal absorption of vitamin B Advanced and Supplemental Topics. The Gastric Parietal Cell and the Mechanism of Acid Secretion; Pepsin and Pepsinogens; Rennin and the Coagulation of Milk; Intrinsic.
Cell Regulation Vol. 2, No. 1 Research Article Free Access Thapsigargin potentiates histamine-stimulated HCl secretion in gastric parietal cells but does not mimic cholinergic responses. C S Chew. Describe the mechanism by which parietal cells secrete HCl into the gastric juice. they have dense microvilli which create a large surface area for the HCl secretion when proteins enter the stomach, the pH of the gastric contents rises -> stimulates gastrin secretion and HCl release-> lower pH -> inhibition of gastrin secretary cells.
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The regulation of gastric HCl secretion by the parietal cell occurs primarily through the regulated recycling of H,K-ATPase. Secretagogue stimulation of the parietal cell initiates HCl secretion by effecting an intracellular signaling and biochemical pathway that culminates with the membrane fusion of intracellular H,K-ATPase-rich tubulovesicles with, and thus, the delivery of the H,K-ATPase Cited by: 3.
Gastric motility and secretion are regulated by neural and humoral mechanisms. For convenience, the physiologic regulation of gastric secretion is usually discussed as being either cephalic or peripheral, which includes both gastric and intestinal influences, although these overlap.
The cephalic influences are vagally mediated responses induced. Secretion is the movement of material from one point to another, e.g. secreted chemical substance from a cell or contrast, excretion, is the removal of certain substances or waste products from a cell or classical mechanism of cell secretion is via secretory portals at the cell plasma membrane called porosomes.
Porosomes are permanent cup-shaped lipoprotein structure at. Paradoxically, in chief cells, unlike most other secretory cells, increased intracellular calcium inhibits rather than stimulates hormone secretion. Inhibition of PTH secretion coincides with the decline in cyclic AMP and the activity of protein kinase A, but the cellular mechanisms.
However, mechanistic details at the cellular levels are required to understand the regulation/secretion of these different peptides derived from gastric X/A-like endocrine cells. Acknowledgments Dr. Taché has received a VA Research Career Scientist Award and National Cited by: This part also explains a model for the transmembrane regulation of adenylate cyclase that shows the mechanisms that cells use in sensing and responding to extracellular conditions.
Part II discusses the early responses of secretory cells including changes in phospholipid metabolism, in electrophysiological events, and in macromolecular. Figure 2. Anatomy of the gastric (oxyntic and pyloric) gland region in the mucosal lining of the stomach (reprinted with permission from the publisher, Mitchell L.
Schubert). - "Gastric acid secretion and gut peptides: mechanisms involved in inflammatory response". Gastric secretion 1. GASTRIC SECRETION 2. OBJECTIVES By the end of the class you should know: Different cells lining gastric mucosa and their secretions, Composition of gastric juice, Mechanism of gastric acid secretion, Phases and regulation of gastric acid secretion, Experimental demonstrations of the role of regulatory mechanisms and Applied aspects.
Irritation of stomach stimulates salivation. When food is introduced in the stomach of a sleeping dog (to avoid psychic effects), salivation takes place after about 20 minutes.
This is also seen in many irritating conditions of stomach, for instance, gastritis, gastric cancer, etc. Increased salivation, before vomiting, is a typical example.
Intestinal stem cells (ISCs) are highly proliferative cells that fuel the continuous renewal of the intestinal epithelium. Understanding their regulatory mechanisms during tissue homeostasis is key to delineating their roles in development and regeneration, as well as diseases such as bowel cancer and inflammatory bowel disease.
Previous studies of ISCs focused mainly on the position of these. K + channels in the secretory membrane of the parietal cell focus on “Gastric parietal cell secretory membrane contains PKA- and acid-activated Kir K + channels”.
Am J Physiol Cell Physiol C–C, doi: /ajpcell Gastric chief cells are primarily activated by ACh. However the decrease in pH caused by activation of parietal cells further activates gastric chief cells.
Alternatively, acid in the duodenum can stimulate S cells to secrete secretin which acts on an endocrine path to activate gastric chief cells. Gastric phase.
% of total gastric acid. Reviewed here is the current knowledge of proton transport mechanisms in mammals. The emphasis is on gastric acid secretion and the role of the H+, K+-ATPase, but molecular and cellular information on other P- V- and F-type H+-ATPases, in bone, kidney, plants and yeast, as well as other cation ATPases, are included for important comparisons.
Human digestive system - Human digestive system - Gastric secretion: The gastric mucosa secretes to litres of gastric juice per day.
Gastric juice renders food particles soluble, initiates digestion (particularly of proteins), and converts the gastric contents to a semiliquid mass called chyme, thus preparing it for further digestion in the small intestine.
The best-known component of gastric juice is hydrochloric acid, the secretory product of the parietal, or oxyntic cell. It is known that the capacity of the stomach to secrete HCl is almost linearly related to parietal cell numbers. When stimulated, parietal cells secrete HCl at a concentration of roughly mM (equivalent to a pH of ).
Localization, cellular products, and morphology of this cell type had been defined earlier by in vivo studies, yielding clear evidence for the function and importance of this cell type in the regulation of acid secretion (8, 25). In vivo studies investigating the secretory process in ECL cells, however, have been complicated by numerous.
which parietal cells secrete gastric acid through a combination of various receptors on the basolateral membrane and an enzyme in the apical secretory canaliculi has been elucidated (3—5). Chew CS, Petropoulos AC. Thapsigargin potentiates histamine-stimulated HCl secretion in gastric parietal cells but does not mimic cholinergic responses.
Cell Regul. Jan; 2 (1)– [PMC free article] Chew CS, Brown MR. Histamine increases phosphorylation of and kDa parietal cell. Effects on other gastric epithelial cell lineages and evidence for a pindependent apoptotic mechanism that operates in a committed progenitor.
Biol. Chem. ; – Li Q, Karam SM. Gordon JI. Diphtheria toxin-mediated ablation of parietal cells in the stomach of transgenic mice. Biol. Chem. ; – Unique to each cell lineage are the secretory proteins they produce and the direction in which they migrate from the isthmus.
The surface mucous cell precursor migrates apically toward the gastric lumen to form an epithelial layer of mucus-secreting cells (“surface-associated mucous cells”; see Fig. 1) (35, 81).On the other hand, the neck cell precursor migrates toward the base of the unit.
Ion channels (IChs) are transmembrane proteins that selectively drive ions across membranes. The function of IChs partially relies on their abundance and proper location in the cell, fine-tuned by the delicate balance between secretory, endocytic, and degradative pathways.
The disruption of this balance is associated with several diseases, such as Liddle’s and long QT syndromes.
Because.Parietal cells (also known as oxyntic or delomorphous cells) are the epithelial cells that secrete hydrochloric acid (HCl) and intrinsic cells are located in the gastric glands found in the lining of the fundus and in the cardia of the stomach.
They contain an extensive secretory network (called canaliculi) from which the HCl is secreted by active transport into the stomach.58 Pardee A. B. G1 events and regulation of cell proliferation. Science Crossref | PubMed | ISI Google Scholar; 59 Peng X. R., Yao X. B., Chow D. C., Forte J.
G., Bennett M. K. Association of syntaxin 3 and vesicle-associated membrane protein (VAMP) with H + /K +-ATPase-containing tubulovesicles in gastric parietal cells.